
STEM Defense
Engage in epic battles against microscopic foes in 'STEM Defense', a strategic tower defense adventure set on a hex-grid. Harness the immune system's power, BUILD your defenses and fend off waves of pathogens, unlock potent cells and upgrades, and evolve your defenses for a grand survival showdown!
Offers
What are keyshops?About STEM Defense

Iimmerses yourself in a strategic battle within the human body, where you manipulate pathways and tower placements on a dynamic hexagonal grid. This educational tower defense game teaches players about the immune system through engaging gameplay, focusing on the defense against microscopic invaders.
Key Features
Path Expansion: Dynamically extend the pathways pathogens travel to strategically shape each level and increase the effectiveness of your defenses.
Tower Placement Strategy: Strategic placement of your towers is essential. Elevate your towers to gain damage bonuses, crucial for optimizing defense effectiveness.
Mutation-Based Upgrades: Enhance your defenses through epigenetic modifications, providing temporary boosts, and genetic mutations for permanent enhancements. This mirrors real-life biological defense mechanisms.
Experience and Genetic Enhancements: Gain experience to unlock advanced defensive capabilities and permanent genetic upgrades, enhancing your ability to combat pathogens.
Varied Enemy Types: Encounter diverse pathogens, each with unique abilities. Develop strategies to handle enemies that can regenerate, accelerate, or spawn additional threats.
Endless Replayability: With a multitude of genetic enhancements and adaptive enemy tactics, each game offers new challenges and decisions, ensuring unique experiences with every playthrough.
Coming Soon: Acquired immunity mechanics!!
Support Independent Development
As a solo developer not well-versed in the art of social media, I rely on the support of players like you. If you've enjoyed "STEM Defense", please help spread the word and make it known to others!
Game details
Game details
Age ratings
Game modes
Languages
Features
STEM Defense price history
Lowest tracked price: €9.75 (Jul 7, 2026) · current best: €9.75.
STEM Defense reviews
100% positive reviews all-time.
STEM Defense — frequently asked questions
Where can I buy STEM Defense at the cheapest price?
Right now the cheapest offer for STEM Defense is €9.75 at Steam. KingsPrice compares 1 offers from 1 stores — official stores and keyshops — and refreshes prices throughout the day.
What is the lowest price STEM Defense has ever been?
The lowest price KingsPrice has tracked for STEM Defense is €9.75 (recorded on Jul 7, 2026). This covers the stores and period we monitor — set a price alert to catch the next drop to that level.
How can I get STEM Defense at a discount?
Create a free price alert on this page and KingsPrice will email you when STEM Defense drops below your chosen price. The biggest discounts usually appear during seasonal Steam sales and publisher promotions — the sale calendar on this page shows the next confirmed event.
System requirements
Minimum
- OS: Windows 10
- Processor: Intel i5
- Memory: 4 GB RAM
- Graphics: NVIDIA GeForce 8600 GT / AMD Radeon HD 2600XT (at least 256 MB video memory) Network: Broadband internet connection
- DirectX: Version 10
- Storage: 500 MB available space
- Sound Card: DirectX compatible
Recommended
- OS: Windows 10
- Processor: Intel Core i5-8400 or AMD Ryzen 5 2600
- Memory: 8 GB RAM
- Graphics: NVIDIA GeForce GTX 1060 6GB or AMD Radeon RX 580 8GB
- DirectX: Version 12
- Storage: 1 GB available space
- Sound Card: DirectX compatible, with latest drivers












